Announcements and Circulars

(1) PROPOSED RE-ELECTION OF DIRECTORS (2) PROPOSED GRANTING OF GENERAL MANDATES TO REPURCHASE SHARES AND TO ISSUE SHARES (3) PROPOSED RE-APPOINTMENT OF RETIRING AUDITOR (4) 2022 PROPOSED OPTION GRANT (5) 2022 PROPOSED AWARD GRANT (6) 2022 PROPOSED PERFORMANCE TARGET AWARD GRANT (7) 2023 PROPOSED OPTION GRANT (8) 2023 PROPOSED AWARD GRANT (9) 2023 PROPOSED PERFORMANCE TARGET AWARD GRANT (10) SUPPLEMENTAL INFORMATION RELATING TO GRANT OF OPTIONS AND AWARDS AND (11) NOTICE OF ANNUAL GENERAL MEETING

Monthly Return of Equity Issuer on Movements in Securities for the month ended 30 April 2023

Notification Letter with Request Form to Non-registered Holders

Notification Letter with Change Request Form to Registered Shareholders

Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 March 2023

(1) GRANT OF OPTIONS (2) PROPOSED GRANT OF OPTIONS (3) GRANT OF AWARDS (4) NON-EXEMPTED CONNECTED TRANSACTIONS - PROPOSED AWARD GRANT TO CONNECTED PERSONS (5) NON-EXEMPT CONNECTED TRANSACTION - PROPOSED PERFORMANCE TARGET AWARD GRANT TO CONNECTED PERSONS (6) UPDATE ON THE PREVIOUS PROPOSED PERFORMANCE TARGET AWARD GRANT TO A CONNECTED PERSON

LIST OF DIRECTORS AND THEIR ROLES AND FUNCTIONS

RESIGNATION OF EXECUTIVE DIRECTOR AND CHIEF OPERATING OFFICER

ANNUAL RESULTS ANNOUNCEMENT FOR THE YEAR ENDED 31 DECEMBER 2022

VOLUNTARY ANNOUNCEMENT BUSINESS UPDATE ON THE APPROVAL OF NEW DRUG APPLICATION IN CHINA FOR XERAVA TM FOR THE TREATMENT OF COMPLICATED INTRA-ABDOMINAL INFECTIONS IN ADULT PATIENTS

DATE OF BOARD MEETING

VOLUNTARY ANNOUNCEMENT

Monthly Return of Equity Issuer on Movements in Securities for the month ended 28 February 2023

Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 January 2023

LIST OF DIRECTORS AND THEIR ROLES AND FUNCTIONS

CHANGE OF INDEPENDENT NON-EXECUTIVE DIRECTOR AND CHANGE OF COMPOSITION OF BOARD COMMITTEES

Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 December 2022

Next Day Disclosure Return

UPDATE IN RELATION TO DISCLOSEABLE TRANSACTION-(1) COLLABORATION AND LICENSE AGREEMENT; AND (2) SHARE ISSUANCE AGREEMENT IN RESPECT OF THE MANUFACTURE, DEVELOPMENT AND COMMERCIALIZATION OF COVID-19 VACCINES AND CERTAIN LICENSED PRODUCTS

Monthly Return of Equity Issuer on Movements in Securities for the month ended 30 November 2022